Variable small protein (Vsp)-dependent and Vsp-independent pathways for glycosaminoglycan recognition by relapsing fever spirochaetes
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چکیده
منابع مشابه
Identification of Relapsing Fever Spirochaetes
Many different opinions are observed if one compares the denomination of the species of relapsing fever spirochaetes by different authors. Brumpt (1) describes 14 different species in his extended Parasitology and Stitts (2) 18, but he admits the possibility of synonyms among them. Napier (3) mentions that the application of names of the countries in which the spirochaetes occur implicates the ...
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A common mechanism of immune evasion in pathogenic bacteria and protozoa is antigenic variation, in which genetic or epigenetic changes result in rapid, sequential shifts in a surface-exposed antigen. In this issue of Molecular Microbiology, Dai et al. provide the most complete description to date of the vlp/vsp antigenic variation system of the relapsing fever spirochaete, Borrelia hermsii. Th...
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In the voltage-sensing phosphatase Ci-VSP, a voltage-sensing domain (VSD) controls a lipid phosphatase domain (PD). The mechanism by which the domains are allosterically coupled is not well understood. Using an in vivo assay, we found that the interdomain linker that connects the VSD to the PD is essential for coupling the full-length protein. Biochemical assays showed that the linker is also n...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2000
ISSN: 0950-382X,1365-2958
DOI: 10.1046/j.1365-2958.2000.01906.x